CRISPR-Cas systems have redefined the landscape of genetic engineering, offering an unprecedented level of precision, efficiency, and versatility in genome editing. This book entitled “Gene Editing by CRISPR-Cas” provides a comprehensive and well-structured approach on the historical context of genetics and gene editing techniques leading to the ground-breaking discovery of CRISPR-Cas systems.
Distinguished by its multidisciplinary scope, this volume not only delves into CRISPR-Cas systems but also examines alternative and next-generation gene-editing technologies. The book aims to inform and engage both general audience with a keen interest in science and biology, as well as professionals and students in related fields. By offering a balanced blend of scientific explanations, real-world applications, the book seeks to empower readers to understand the potential of CRISPR technology and its impact across diverse domains such as medicine, agriculture, biotechnology, and diagnostics, while addressing the ethical, regulatory, and biosafety considerations essential for responsible implementation. Furthermore, this book engages in a discussion on the future directions and broader impacts of CRISPR technologies, providing valuable insights into the evolving landscape of genome engineering and its implications for scientific advancements.
Key Features:
This book is written in a clear and accessible manner, making complex scientific concepts understandable to a general audience without overwhelming them with technical jargon.
This book provides a comprehensive exploration of the discovery and evolution of CRISPR technology, delving into the underlying science and its transformative capabilities. It serves as an excellent introduction to both the technical intricacies and the human implications of this groundbreaking technology.
This book provides an in-depth exploration of the potential uses of CRISPR across multiple domains, with a particular focus on genetic disease treatment, cancer studies, agricultural advancements, HIV, blood disorders, neurological conditions, insect biology, microbial engineering, and both infectious and non-infectious diseases.
Furthermore, this book also provides critical analysis of bioethics, safety concerns, and regulatory frameworks, providing a responsible perspective on genome editing.
CRISPR-Cas Systems: The Molecular Scissors
Bashir Ahmad Malla, Aarif Ali, Nuzhat Khursheed, Mohammad Saleem Bhat, Farhat Jabeen, Javeed Iqbal Ahmad Bhat
Beyond CRISPR-Cas9 System: Other Gene Editing Technologies
Aarif Ali, Mohammad Saleem Bhat, Javeed Iqbal Ahmad Bhat, Sadhna Aggarwal, Sheikh Bilal Ahmad
CRISPR-Cas Systems in Genetic Diseases
Zainab Manzoor, Umar Rasool, Arshid Reshi, Aarif Ali
CRISPR-Cas Systems in Agriculture
Farkhanda Jabeen, Noreen Aasim, Farheen Shafique
CRISPR-Cas Systems in Insects and Other Arthropods
Arjumand John, Amaninder Kaur Riat, Kaisar Ahmad Bhat, Aarif Ali
CRISPR-Cas Systems in Cancer Biology and Therapeutics
Gh Jeelani Mir, Aarif Ali, Nisar ul Ashraf, Javeed Iqbal Ahmad Bhat, Showkat Ahmad Ganie, Sheikh Bilal Ahmad, Rabia Hamid
CRISPR-Cas systems in diagnosis of infectious and non-infectious diseases
Aarif Ali, Javeed Iqbal Ahmad Bhat, Farheen Shafique
CRISPR-Cas Systems in Hemolytic Diseases
Huma Hameed, Mahtab Ahmad Khan, Saleha Faheem, Muhammad Zaman, Tooba Mehboob, Tehseen Riaz, Naila Tabassam
CRISPR-Cas Systems in Neurological diseases
Aarif Ali, Bashir Ahmad Malla, Mohammad Saleem Bhat, Javeed Iqbal Ahmad Bhat
CRISPR-Cas System in Microbes
Tooba Mehboob, Naila tabassam, Huma Hameed, Muhammad Zaman, Mahtab Ahmad Khan, Imtiaz Majeed, Tehseen Riaz
Current vectors for in-vivo delivery of CRISPR-Cas9 System
Nausheen Shafi, Tasaduq Manzoor, Irfan Hussain, Junaid Nazir, Aarif Ali, Ubaid Gani, Lateef Ahmad Dar, Yaawar Bashir Mir, Syed Mudasir Ahmad, Meena Godha, Priyanka Jha
Ethical Issues in Genome Editing
Huma Hameed, Muhammad Zaman, Saleha Faheem, Mahtab Ahmad Khan, Shazia Akram Ghumman, Tooba Mehboob, Naila Tabassam
Biography
Dr. Aarif Ali
Dr. Aarif Ali holds Doctor of Philosophy in Clinical Biochemistry from University of Kashmir, Srinagar, Jammu and Kashmir, India. Dr. Ali has obtained his Masters in Clinical Biochemistry from the University of Kashmir, Srinagar, Jammu and Kashmir, India. Dr. Aarif Ali serves as reviewer of several high-impact national as well as international scientific journals. Dr. Ali has published books on Pharmacogenomics From Discovery to Clinical Implementation (Elsevier, ISBN 978-0-443-15336-5), BIOLOGICAL INSIGHTS OF MULTI-OMICS TECHNOLOGIES IN HUMAN DISEASES (Elsevier, ISBN 978-0-443-23971-7) and Fundamentals of Biochemistry (NIPA, August 2024, ISBN: 9789358872682).
Dr. Ali has collaboratively worked and published more than 100 research publications in different reputed national as well as international journals. Dr. Ali’s has been awarded with Young Scientist Award at the AI-CIAS-2024. Dr. Ali’s contributions to the scientific community extend to numerous research publications, covering various aspects of human health. Dr. Ali’s dedication to research and his passion for contributing to scientific knowledge make him a valuable asset to the academic and scientific community.
Dr. Farheen Shafique
Dr. Farheen Shafique is a highly accomplished Zoologist and Molecular Biologist with a strong academic background and extensive research experience. She holds Ph.D. in Zoology and Molecular Biology, obtained jointly from the University of Azad Jammu and Kashmir, Pakistan, and the University of Sheffield, UK. Prior to that, she completed her Master's in Zoology/Molecular Biology. Farheen's dedication to research has earned her prestigious awards and scholarships, including the Commonwealth PhD Split-site Scholarship in the United Kingdom and the International Research Support Initiative Program (IRSIP) PhD Fellowship by the Higher Education Commission of Pakistan. Farheen's contributions extends to numerous research publications, covering topics ranging from infectious diseases, vaccination, and human health to ecological impacts of climate change and biodiversity preservation.
